100 Scientific Studies of Hydrogen Water

Ionized Water, Hydrogen Water, Hydrogen Gas & Free Hydrogen

The body can be helped or healed naturally with free-hydrogen. Free-hydrogen is a unique molecule of two hydrogens, bonded together, but not bonded to any other elements. You can only get free-hydrogen in ionized water, hydrogen water or hydrogen gas. Other names for free hydrogen are: molecular hydrogen, diatomic hydrogen or H2.

The most widely used and possibly the most therapeutic form of free-hydrogen is in hydrogen water. Hydrogen water can be produced by either a water ionizer or a hydrogen machine, and in either case is very therapeutic, as the studies on this page show. There is nothing more holistic than hydrogen. Every cell needs it.

Regular water should not be confused with hydrogen water. It has hydrogen in it of course, H2O, but the hydrogen in regular water is not free and cannot fight free-radicals.

There are two ways to get hydrogen water: ionized water (water ionizer) and hydrogen water (hydrogen water machine). My personal preference is the water ionizer, because my body needs more alkalinity to help keep body detoxified. Here's my testimonial.

The research on this page shows the positive effects that hydrogen water, hydrogen by itself (as a gas) and hydrogen in ionized water have on the body. On this page you can click on links to both the human studies and animal studies, below. Within each category of disease, I have placed the human studies first, followed by the animal studies.

The terrific therapeutic benefits of water ionizers (ionized water), hydrogen water machines (hydrogen water) and hydrogen gas machines (hydrogen gas) have been demonstrated thousands of times in in these scientific studies, and more studies are being conducted every day. I have picked out a little over a hundred of these studies to list and link to on this page. See for yourself the enourmous and growing proof that alkaline ionized water and hydrogen water can significantly help the body.

Learn more about these very positive and important research topics. Use these links to skip right to the section on this page that you want, or scroll down, either way. Then the back-arrow will bring you back to this main chart.

BRAIN-NERVES

HEART

DIABETES

CANCER

CARDIO-VASCULAR

KIDNEYS

INTESTINES-STOMACH

CHOLESTEROL

LIVER

RESPIRATORY DISEASE

ANTIOXIDANT

ANTI-AGING

EYES

OTHER

SKIN

About the Articles

These are a compilation of a variety of hand-picked, relevant articles, which are a good sample of the scientific literature about hydrogen water, water ionizers, and hydrogen gas to date. Each study listed is linked to the published abstract of the article. Each of the article links will open up a new page in your browser. Note: Ionized water is typically called "electrically reduced water" or ERW in the studies. Hydrogen, in hydrogen gas and hydrogen water, is often called "molecular hydrogen". Ionized water is not the same as hydrogen water, but can be called hydrogen water because it has a lot of molecular hydrogen in it. Ionized water is produced in a water ionizer and hydrogen water is produced with either a hydrogen water machine or hydrogen gas generator.

HEART

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2017	Miocardial Infarction	The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　- First Pilot Study in Humans. [Human study shows inhaling hydrogen is safe and improves the markers of hypertension.]
2019	Hypertension	Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. [Animal study shows hydrogen reduces hypertension and left ventricular hypertrophy.]
2018	Chronic Heart Failure	Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats. [Animal study shows hydrogen reduces the symptoms of chronic heart failure.]
2016	Cardiopulmonary Resuscitation	Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. [Animal study shows hydrogen improves cardiac function after cardiac arrest.]
2015	Cardiac Dysfunction	Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice. [Animal study shows hydrogen improves heart function and reduces heart dysfunction caused by high glucose levels caused by diabetes.]
2015	Atherosclerosis	Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice. [Animal study shows hydrogen has an inhibitory effect and improves the stability of atherosclerotic plaque]
2012	Cardiac Arrest	H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. [Animal study shows hydrogen reduces the mortality rate and increases the rate of resuscitation rate after cardiac arrest.]
2014	Cardiac Arrest	Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management [Animal study shows hydrogen improves the outcome and resuscitation rate after cardiac arrest.]
2018	Vascular Aging of Aorta	Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice [Animal study shows hydrogen decreased the markers of vascular aging and cholesterol levels]

CANCER

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2019	Colorectal cancer	Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer [Human study shows hydrogen reverses imbalances caused by chemotherapy and improved prognosis of stage IV cancer patients.]
2017	Colorectal Cancer [LIVER]	Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. [A controlled, randomized, single-blind human clinical study shows that hydrogen water alleviates liver injury due to chemotherapy.]
2018	Lung Cancer	Hydrogen gas inhibits lung cancer progression through targeting SMC3. [Animal study shows hydrogen inhibits lung cancer progression.]
2017	Colon Cancer Inhibition	Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. [Animal study shows hydrogen improves the survival rate of mice with colon cancer and has anticancer functions, particularly in combination with 5-fluorouracil.]
2013	Mitochondria's huge Influence on Cancer	Mitochondria and Cancer, Past, Present and Future [A summary of the research on mitochondria's influence on cancer.
2009	Alleviates Cancer Drug Side-Effects	Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice [Animal study shows hydrogen helps protect against cisplatin-induced toxicity showing it has potential for improving the quality of life of patients undergoing chemotherapy.]

CHRONIC LOWER RESPIRATORY DISEASE

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2017	anti-inflammatory [RHINITIS]	Effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells of allergic rhinitis guinea pigs model [Animal study shows hydrogen reduces allergic inflammation.]
2017	anti-inflammatory [Lung Injury from O2 THERAPY]	Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1 [Animal study shows that hydrogen has a protective effect against oxygen induced lung injury and reduces edema.]
2015	anti-inflammatory [EXERCISE]	Hydrogen-rich water inhibits mitochondrial oxidative stress and inflammation in the skeletal muscle after eccentric exercise [Animal study shows [Animal study shows hydrogen reduces inflammation after exercise.]
2009	Immune System	The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice. [Animal study shows hydrogen water assists immune responsiveness.]

Brain & Nerves: STROKE

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2017	Cerebral infarction (acute)	Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection [A randomized controlled human clinical study of patients with acute cerebral infarctions showed no harmful effects and better recovery rates.]
2017	Neuroblastoma	Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis. [A human cultured neuroblastoma, pre-treated with hydrogen, was protected against H2O2 induced cell death.]
2019	Glioblastoma	Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation. [Animal study shows reduction in common brain tumors by inhaling hydrogen.]
2018	Traumatic Brain Injury	Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway. [Animal study shows hydrogen-rich water has a neuroprotective effect on the brain.]
2018	Mitochondria	Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages. [Animal study shows the neuroprotective effect of hydrogen on the neurons in the spinal chord. Hydrogen was also seen to help the neurons and their mitochondria to heal after damage.]
2018	After stroke	Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. [Animal study showing the neuroprotective effect of hydrogen.]
2018	Stroke	Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion independent of anti-necroptosis. [Animal study showing that hydrogen helps improve recovery after stroke.]
2018	Severe Brain Injury	Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model. [Animal study showing that hydrogen has a neuroprotective effect on the brain and helps prevent or reduce the effects of brain injury.]
2016	Brain injury	Effect of hydrogen-rich water on the angiogenesis in lesion boundary brain tissue of traumatic brain [Animal study shows hydrogen-rich water promotes angiogenesis and improves nerve function.]
2015	Neuroprotective	Hydrogen has a neuroprotective effect via activation of Nrf-2/HO-1 pathway in ischemia reperfusion rat [Animal study shows that hydrogen has a neuroprotective effect against stroke.]
2016	Brain damage	Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats. [Animal study shows hydrogen reduces the effects of brain damage and prevents inflammation.]
2016	Brain infarction	Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats - A possible new hydrogen resource for clinical use. [Animal study shows hydrogen has a neuroprotective effect against cerebral damage.]
2015	Stroke	Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats [Animal study shows hydrogen water can improve neurological function after a stroke.]
2015	Protects Against Stroke	Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. [Animal study shows hydrogen water helps to reduce brain infarct volume and improve neurological function following an induced brain injury.]

Brain & Nerves: ALTZHEIMER'S, MULTIPLE SCLEROSIS & PARKINSON'S DISEASE

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2013	Parkinson's	Pilot study of H2 therapy in Parkinson's disease: A randomized double‐blind placebo‐controlled trial [A human controlled trial shows that drinking Hydrogen water was safe, and well tolerated. The patients who drank it showed significant improvement, while the control group who didn’t drink the hydrogen water worsened.]
2019	Vascular Dementia	FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia. [Animal study shows drinking hydrogen water inhibits neuron loss and alleviates memory impairments due to vascular dementia.]
2019	Glioblastoma	Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation. [Animal study shows reduction in common brain tumors by inhaling hydrogen.]
2018	Mitochondria	Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages. [Animal study shows the neuroprotective effect of hydrogen on the neurons in the spinal chord. Hydrogen was also seen to help the neurons and their mitochondria to heal after damage.]
2018	Mild Cognitive Impairment	Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. [Animal study showing that hydrogen water helps to suppress dementia and other oxidative stress.]
2018	Cognitive Impairment	Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance. [Animal study showing that hydrogen significantly helps cognitive behavior and reduced oxidative stress and inflammation in the brain. This study noted that there was an even more profound effect in the female brains than male.]
2015	Multiple Sclerosis	Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. [Animal study shows hydrogen water helps to both delay the onset of and reduce the severity of induced multiple sclerosis.]
2015	Altzheimer's	Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. [Animal study shows hydrogen water reduces reactive oxygen induced cell death and stimulates healing.]
2014	Age related Neurological Diseases	Electrochemically Reduced Water Protects Neural Cells from Oxidative Damage [Animal study shows hydrogen water protects cells from oxidative stresses.]

DIABETES

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2008	Diabetes [GLUCOSE TOLERANCE]	Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. [A randomized double-blind human study shows hydrogen helped decrease oxidative stress and insulin resistance and improved glucose metabolism.]
2013	Diabetes [GLUCOSE UPTAKE]	Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle [Animal study shows hydrogen improves glucose control.]
2011	Diabetes [Pt NANOPARTICLES]	Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles [Animal study shows both hydrogen water and the nano platinum in ionized water improve glucose signaling pathways.]
2006	Diabetes [ANTI-DIABETIC EFFECTS]	Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice. [Animal study shows hydrogen improves blood glucose control.]
2006	Diabetes [BETA CELL PROTECTION]	Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. [Animal study shows hydrogen improves blood glucose tolerance, increases blood insulin and reduces blood glucose.]
2005	Diabetes [BETA CELL PROTECTION]	Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. [Animal study shows hydrogen enhances glucose-sensitivity, glucose response of beta-cells and protects pancreatic beta-cells from alloxan-induced cell damage.]

KIDNEYS

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2018	Dialysis	Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study [This is a human study spanning 3 years and shows that adding hydrogen to the dialysis solution benefits dialysis patients’ prognosis.]
2003	Kidney Disease	Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. [This is a human study which shows that ionized water is effective in reducing oxidative stress and improving overall health of patients with kidney disease. This is important, because hemodialysis increases oxidative stress and to be able to combat that would naturally improve the patient prognosis.]
2018	Toxicity	Nephroprotective effect of electrolyzed reduced water against cisplatin-induced kidney toxicity and oxidative damage in mice [Animal study shows ionized water helps to protect the kidneys against damage when “Cisplatin” (a chemotherapy drug) is given]
2017	Renal Injury & Fibrosis	Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor [Animal study shows hydrogen water helps to inhibit the development of fibrosis in kidneys.]
2010	Renal Injury	Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats [Animal study shows hydrogen water helped healing after a kidney injury.]
2014	Renal injury	Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. [Animal study shows hydrogen water helps to alleviate renal injury

LIVER

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2017	Chemo: Protects Liver	Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. [This is a human study which shows that H2 helps to maintain microcirculation and the health of the mitochondria in patients being treated with chemotherapy.]
2011	Radiotherapy for liver tumors	Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. [This is a human study which shows that drinking hydrogen-rich water reduces the stress markers connected with radiation therapy.]
2013	Chronic Hepatitis B	Effect of Hydrogen‐Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B [This is a human study showing that hydrogen rich water helps to alleviate oxidative stress in patients with chronic Hepatitis B.]
2018	Liver Injury	Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study [Animal study shows H2 to be effective in maintaining microcirculation and mitochondrial function in liver cells and suppressing cellular death in the liver after cardiac death.]
2018	Liver & Cholesterol	Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice [Animal study shows alkaline ionized water assists the intestinal environment and has beneficial roles for health in terms of cholesterol metabolism and liver protection.]
2017	Liver Injury	Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway [Animal study shows that a high concentration of hydrogen improves liver function and may protect the liver against I/R injury, which is the injury when blood supply returns to tissue after a period of absence.]
2017	Protect Against Sepsis	Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury [Animal study shows drinking hydrogen water prolongs life and reduces cell death and oxidative stress in mice with sepsis (a life-threatening response to infection).]
2009	Liver	Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. [Animal study shows ionized water protects against liver damage.]

CHOLESTEROL

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2013	Cholesterol level Balancing	Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. [This is a human study which shows drinking ionized water helps cholesterol levels.]
2018	Liver & Cholesterol	Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice [Animal study shows drinking ionized water helps intestinal fermentation.]

INTESTINES & STOMACH

YEAR	TOPIC/SUBJECT	TITLE OF SCIENTIFIC ARTICLE
2019	Gut Flora	Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China [This is a human study which shows hydrogen-rich water was healthy for gut flora]
2019	Gastrointestinal Symptoms	Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms [This is a human study which shows alkaline ionized water is effective in relieving abdominal complaints]
2018	Irritable Bowel Syndrome with Diarrhea	Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study [This is a human study which shows alkaline ionized water was helpful in improving the symptoms of diarrhea and irritable bowel syndrome.]
2005	Intestinal Health	Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water. [This is a human study which shows that alkaline ionized water assists to properly balance the gut microflora.
2018	Protects-Good Bacteria	Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and Lactulose in Female Piglets Fed a Fusarium Toxin-Contaminated Diet [Animal study shows that hydrogen-water has shown a protective effect on the balance of intestinal microbiota.]
2018	Intestinal Environment	Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice [Animal study shows alkaline ionized water has benefit to intestinal microbes]
2018	GI Toxicity	Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota [Animal study shows that drinking hydrogen-rich water improved the prognosis of mice undergoing radiation and was protective of the intestines.]
2017	Inflammatory Bowel Disease	Hydrogen-rich water protects against inﬂammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression [Animal study shows shows hydrogen-rich water protects against inflammatory bowel disease.]
1996	Intestinal Health	Physiological effects of alkaline ionized water: Effects on metabolites produced by intestinal fermentation [Animal study shows alkaline ionized water was healthy for the intestines.]

SKIN

YEAR	TOPIC/SUBJECT	TITLE OF SCIENTIFIC ARTICLE
2018	Psoriasis	Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques [This is a human study which shows hydrogen water bathing is beneficial to psoriasis.]
2013	Skin Ulcers	Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro [This is a human study which shows intake of hydrogen water helps the reconstruction of normal skin cells.]
2012	Skin Diseases	Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. [This is a human study which shows hydrogen helped with the prognosis of inflammation of the skin.]
2012	Wrinkles	Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. [This is a human study which shows hydrogen water bathing helps to repress UVA-induced wrinkles.
2013	Dermatitis	The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. [Animal study shows hydrogen water has a positive effect on atopic dermatitis.]

ANTI-INFLAMMATORY

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2014	Sports-Related Soft Tissue Injuries	Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. [Human study of professional athletes shows faster recovery times when injured for those who were given hydrogen supplements daily during the season.]
2017	anti-inflammatory [RHINITIS]	Effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells of allergic rhinitis guinea pigs model [Animal study shows hydrogen reduces allergic inflammation.]
2017	anti-inflammatory [PANCREATITIS]	Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss. [Animal study shows hydrogen helped to prevent and reduce pancreatitis.]
2017	anti-inflammatory [Lung Injury from O2 THERAPY]	Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1 [Animal study shows that hydrogen has a protective effect against oxygen induced lung injury and reduces edema.]
2016	anti-inflammatory [PANCREATITIS]	Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis [Animal study shows hydrogen has a protective effect against oxidative damage and reduces inflammation.]
2016	anti-inflammatory [ARTHRITIS]	Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress [Animal study shows hydrogen slows down the progression of rheumatoid arthritis.]
2015	anti-inflammatory [EXERCISE]	Hydrogen-rich water inhibits mitochondrial oxidative stress and inflammation in the skeletal muscle after eccentric exercise [Animal study shows [Animal study shows hydrogen reduces inflammation after exercise.]
2001	anti-inflammatory [LIVER]	Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. [Animal study shows hydrogen has an anti-inflammatory effect.]
2009	Immune System	The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice. [Animal study shows hydrogen water assists immune responsiveness.]

ANTI-OXIDANT

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2012	Platelets	Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study [This is a human and animal study which shows hydrogen may inhibit collagen-induced platelet aggregation.]
2016	Antioxidant	Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and elomerase Activity [in vitro study shows that commercial hydrogen water is effective in antioxidant properties.]
2017	Bone-Health	Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis. [Animal study shows hydrogen prevents steroid-induced osteonecrosis.]
2011	Eyes - Cornea	Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. [Animal study shows hydrogen helps prevent blindness caused by alkali burn.]
2017	Obesity	Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet. [Animal study shows hydrogen-rich water suppressed body weight gain and reduced oxidative stress.]
2011	Obesity & Diabetes	Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. [Animal study shows hydrogen stimulated energy metabolism, improving obesity, diabetes and metabolic syndrome.]

ANTI-AGING

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2018	Reduction of Senescence-Associated Cells	Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo [Animal study shows hydrogen is a protective anti-aging treatment.]
2017	Anti-Aging & Cell Death	Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage [Animal study shows hydrogen protects against aging and cell death.]
2016	Longevity	Alkaline Water and Longevity [Animal study shows alkaline ionized water improves strength and longevity of mice.]
2010	Anti-Aging; Bones	Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. [In vitro study shows hydrogen prolongs the lifespan of cells.]
2013	Increased Lifespan	Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans. [Animal study shows hydrogen helps to resist oxidative stress and aging.]
1997	Protects DNA	Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage. [Animal study shows hydrogen helps to protect DNA and scavenges harmful radicals.]

EYES

YEAR	TOPIC/SUBJECT	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2019	Retinal Vein Occlusion	Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression. [Animal study shows hydrogen helps alleviate retinal oedema and improve its function.]
2011	Cornea	Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. [Animal study shows hydrogen helps prevent blindness from alkali burn.]
2010	Retina	Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Oharazawa H1, Igarashi T, Yokota T. [Animal study shows hydrogen loaded eye drops are highly useful and neuroprotective]

OTHER

YEAR	TOPIC/SUBJECT	LINK	TITLE/DESCRIPTION OF SCIENTIFIC ARTICLE
2011	Radiotherapy	PubMed	Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. [A randomized placebo controlled human study shows therapeutic benefits for drinking hydrogen-rich water before, during and after radiation treatments]
2011	Weight Loss	HighBeam	The effect of daily consumption of 2 liters of electrolyzed water for 2 months on body composition and several physiological parameters in four obese subjects: a preliminary report. [This was a human trial to see if alkaline ionized water would influence the ability of four obese patients to lose weight. The average weight loss reported during the two-month trial was 12 pounds. No other variable was introduced. No toxins were in the water, yet increased toxins were in the urine test, which indicates the body was able to detox several of the tested heavy metals.]
2016	Blood Viscosity	BioMed Central	Effect of electrolyzed high-pH alkaline water on blood viscosity in healthy adults [Human study shows high pH water to be more hydrating.]
2018	Pregnancy: Protective Benefits Spread to Newborn	PubMed	Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model. [Animal study shows that giving H2 to the mother is protective for the newborn]
2017	Hemorrhagic Shock	PubMed	Hydrogen gas inhalation inhibits progression to the "irreversible" stage of shock after severe hemorrhage in rats. [Animal study shows treatment with H2 inhalation stabilizes the blood pressure until curative treatment can be performed.]
2014	Hearing Loss (noise-induced)	PubMed	Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. [Animal study shows H2 inhalation is protective against noise induced hearing loss.]
2016	Sepsis	PubMed	Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis. [Animal study shows molecular hydrogen improves chances of survival]
2016	Motor Deficits	Tandfon-line	Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice [Animal study shows hydrogen improves prognosis for muscular dystrophy]
2016	Bladder	PubMed	Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction. [Animal study shows H2 is protective against bladder dysfunction.]
2009	Hearing: Auditory Hair Cells	PubMed	Hydrogen protects auditory hair cells from free radicals. [In vitro study shows hydrogen to be protective against cell death of auditory hair cells.]
2014	Prevention Medicine	PubMed	Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.
2009	Metabolic Acidosis	PubMed	Ionized alkaline water: new strategy for management of metabolic acidosis in experimental animals [Animal study shows alkaline ionized water can manage metabolic acidosis safely.]
2009	Hangovers	PubMed	Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats [Animal study shows drinking alkaline ionized water has a detox effect from ethanol]
2017	ERW Superior to other H2Water	PubMed	Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water. [In vitro study shows that alkaline ionized water has additional antioxidative factor, likely to be platinum nanoparticles, which makes it superior to other hydrogen applications for scavenging radicals.]

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100 Scientific Studies of Hydrogen Water