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Scientific Studies of Therapeutic Healing

Ionized Water, Hydrogen Water & Hydrogen Gas

The body (and its many parts) and diseases of all kinds have been found to have been helped or healed naturally from the use of ionized water, hydrogen water and hydrogen gas. 

The terrific therapeutic benefits of water ionizers (ionized water), hydrogen water machines (hydrogen water) and hydrogen gas machines (hydrogen gas) have been demonstrated thousands of times in scientific studies. You can see over 100 of these studies below.

Learn more about these very positive and important research topics. Use these anchor-links to skip right to the section on this page that you want, or scroll down, either way. 

[BRAIN-NERVES]

[ANTI-INFLAMMATORY] 

[DIABETES] 

[CANCER]  

[HEART]

[KIDNEYS] 

[INTESTINES-STOMACH]

[CHOLESTEROL]

[LIVER]

[SKIN]

[ANTIOXIDANT]

[ANTI-AGING]  

[EYES] 

[OTHER] 

 

About the Articles

These articles are a compilation of a variety of hand-picked, relevant articles, which are a good sample of the scientific literature about hydrogen water, water ionizers, and hydrogen gas to date. Each study listed is accompanied by a link to the published abstract of the article. The link will open up a new page in your browser. Note: Ionized water is typically called "electrically reduced water" or ERW in the studies. Hydrogen, in hydrogen gas and hydrogen water, is often called "molecular hydrogen". Ionized water is not the same as hydrogen water, but can be called hydrogen water because it has a lot of molecular hydrogen in it. Ionized water is produced in a water ionizer and hydrogen water is produced with either a hydrogen water machine or hydrogen gas generator.

Brain & Nerves

YEAR

TOPIC/SUBJECT

 LINK

TITLE OF SCIENTIFIC ARTICLE

2019

Vascular Dementia

PubMed

FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia.

2019

Glioblastoma PubMed

Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation.

2018

Brain Lesion

PubMed

Molecular hydrogen alleviates asphyia-induced neuronal cyclooxygenase-2 expression in newborn pigs.

2018

Traumatic Brain Injury

PubMed

Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway.

2018

Mitochondria

PubMed

Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages.

2018

After stroke

PubMed

Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway.

2018

Mild Cognitive Impairment

PubMed

Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.

2018

Stroke

PubMed

Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion independent of anti-necroptosis.

2018

Cognitive Impairment

PubMed

Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance.

2018

Severe Brain Injury

PubMed

Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model.

2017

Neuroprotective

PubMed

Molecular Hydrogen as a Neuroprotective Agent.

2017

Neuroblastoma

PubMed

Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis.

2017

Cerebral infarction (acute)

PubMed

Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection

2016

Brain injury

IJCEP

Effect of hydrogen-rich water on the angiogenesis in lesion boundary brain tissue of traumatic brain

2013

Parkinson's

Online Library

Pilot study of H2 therapy in Parkinson's disease: A randomized doubleblind placebocontrolled trial

2015

Multiple Sclerosis

PubMed

Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice.

2015

Neuroprotective

IJCEP

Hydrogen has a neuroprotective effect via activation of Nrf-2/HO-1 pathway in ischemia reperfusion rat

2016

Brain damage

PubMed

Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats.

2016

Brain infarction

PubMed

Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats - A possible new hydrogen resource for clinical use.

2015

Stroke

PubMed

Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats

2015

Altzheimer's

PubMed

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.

2015

Protects Against Stroke

PubMed

Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins.

2014

Age related Neurological Diseases

PubMed

Electrochemically Reduced Water Protects Neural Cells from Oxidative Damage

2014

Traumatic Brain Injuries

PubMed

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.

2013

Brain Injury [hemorrhage]

PubMed

Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice.

2011

Nerve & Brain Protection

PubMed

The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles

2012

Neurodegenerative diseases

PubMed

Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases

2009

Stress-Induced Impairments

PubMed

Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.

 ANTI-INFLAMMATORY

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2017

anti-inflammatory [RHINITIS]

PubMed

Effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells of allergic rhinitis guinea pigs model

2017

anti-inflammatory [PANCREATITIS]

PubMed

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss.

2017

anti-inflammatory [Lung Injury from O2 THERAPY]

PubMed

Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1

2016

anti-inflammatory [PANCREATITIS]

PubMed

Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis

2016

anti-inflammatory [ARTHRITIS]

PubMed

Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress

2015

anti-inflammatory [EXERCISE]

WHOCC

Hydrogen-rich water inhibits mitochondrial oxidative stress and inflammation in the skeletal muscle after eccentric exercise

2014

Sports-Related Soft Tissue Injuries

PubMed

Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries.

2001

anti-inflammatory [LIVER]

PubMed

Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.

2009

Immune System

PubMed

The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice.

 DIABETES

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2013

Diabetes [GLUCOSE UPTAKE]

PubMed

Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle

2011

Diabetes [Pt NANOPARTICLES]

PubMed

Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles

2008

Diabetes [GLUCOSE TOLERANCE]

PubMed

Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.

2006

Diabetes [ANTI-DIABETIC EFFECTS]

PubMed

Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice.

2006

Diabetes [BETA CELL PROTECTION]

PubMed

Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice.

2005

Diabetes [BETA CELL PROTECTION]

PubMed

Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species.

CANCER

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2019

Colorectal cancer

PubMed

Hydrogen gas restores exhausted CD8+ T cells in patients with advanced

2018

Lung Cancer

PubMed

Hydrogen gas inhibits lung cancer progression through targeting SMC3.

2017

Colorectal Cancer [LIVER]

PubMed

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.

2017

Colon Cancer Inhibition

PubMed

Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer.

2012

Fibrosarcoma

PubMed

Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells

2009

Alleviates Cancer Drug Side-Effects

PubMed

Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice

2005

Cancer Prevention

PubMed

Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation.

2008

Cancer - Tumor Inhibition

PubMed

Inhibitory effect of electrolyzed reduced water on tumor angiogenesis.

2009

Leukemia

PubMed

Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione.

2008

Tumor Angiogenesis

PubMed

Inhibitory effect of electrolyzed reduced water on tumor angiogenesis.

HEART

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2019

Hypertension

PubMed

Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.

2018

Chronic Heart Failure

PubMed

Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats.

2017

Miocardial Infarction

PubMed

The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans.

2016

Cardiopulmonary Resuscitation

PubMed

Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats.

2015

Cardiac Dysfunction

PubMed

Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.

2015

Atherosclerosis

PubMed

Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.

2012

Cardiac Arrest

PubMed

H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model.

2014

Cardiac Arrest

PubMed

Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management

2018

Vascular Aging of Aorta

Nature

Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice

KIDNEYS

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2019

Kidney Disease

PubMed

Effects of hydrogen-rich water in a rat model of polycystic kidney disease.

2018

Dialysis

PubMed

Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study

2018

Toxicity

Science Direct

Nephroprotective effect of electrolyzed reduced water against cisplatin-induced kidney toxicity and oxidative damage in mice

2017

Renal Injury & Fibrosis

Jstage

Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor

2010

Renal Injury

Academic

Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats

2014

Renal injury

PubMed

Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats.

2003

Kidney Disease

PubMed

Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.

LIVER

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2018

Liver Injury

Springer

Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study

2018

Liver & Cholesterol

PubMed

Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice

2017

Chemo: Protects Liver

PubMed

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.

2017

Liver Injury

Science Direct

Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway

2017

Protect Against Sepsis

Journals

Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury

2011

Radiotherapy for liver tumors

PubMed

Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.

2013

Chronic Hepatitis B

ASCPT

Effect of HydrogenRich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B

2009

Liver

PubMed

Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice.

CHOLESTEROL

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2018

Liver & Cholesterol

PubMed

Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice

2013

Cholesterol level Balancing

PubMed

Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

INTESTINES & STOMACH

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2019

Gut Flora

PubMed

Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China

2019

Gastrointestinal Symptoms

PubMed

Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms

2018

Protects-Good Bacteria

PubMed

Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and Lactulose in Female Piglets Fed a Fusarium Toxin-Contaminated Diet

2018

Intestinal Environment

PubMed

Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice

2018

GI Toxicity

PubMed

Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota

2017

Inflammatory Bowel Disease

PubMed

Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression

2018

Irritable Bowel Syndrome with Diarrhea

PubMed

Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study

1996

Intestinal Health

Ionza

Physiological effects of alkaline ionized water: Effects on metabolites produced by intestinal fermentation

2005

Intestinal Health

PubMed

Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water.

SKIN

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2018

Psoriasis

PubMed

Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques

2013

Skin Ulcers

PubMed

Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro

2013

Dermatitis

PubMed

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice.

2012

Skin Diseases

PubMed

Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers.

2012

Wrinkles

PubMed

Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.

ANTI-OXIDANT

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2016

Antioxidant

Ioniun

Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and elomerase Activity

2017

Bone-Health

PubMed

Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.

2012

Platelets

PubMed

Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study

2011

Eyes - Cornea

PubMed

Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.

2017

Obesity

PubMed

Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet.

2011

Obesity & Diabetes

PubMed

Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.

ANTI-AGING

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2018

Reduction of Senescence-Associated Cells

PubMed

Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo

2017

Anti-Aging & Cell Death

PubMed

Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage

2016

Anti-Aging; Antioxidant; Anti-Inflammatory

Ioniun

Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and elomerase Activity

2010

Anti-Aging; Bones

PubMed

Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials.

2013

Increased Lifespan

PubMed

Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans.

1997

Protects DNA

PubMed

Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage.

EYES

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2019

Retinal Vein Occlusion

PubMed

Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression.

2011

Cornea

PubMed

Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.

2010

Retina

PubMed

Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Oharazawa H1, Igarashi T, Yokota T

OTHER

YEAR

TOPIC/SUBJECT

LINK

TITLE OF SCIENTIFIC ARTICLE

2018

Pregnancy: Protective Benefits Spread to Newborn

PubMed

Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model.

2017

Shock

PubMed

Hydrogen gas inhalation inhibits progression to the "irreversible" stage of shock after severe hemorrhage in rats.

2014

Hearing Loss (noise-induced)

PubMed

Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species.

2016

Sepsis

PubMed

Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

2016

Motor Deficits

Tandfon-line

Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice

2016

Blood Viscosity

BioMed Central

Effect of electrolyzed high-pH alkaline water on blood viscosity in healthy adults

2016

Bladder

PubMed

Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction.

2009

Hearing: Auditory Hair Cells

PubMed

Hydrogen protects auditory hair cells from free radicals.

2014

Prevention Medicine

PubMed

Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.

2011

Radiotherapy

PubMed

Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.

2009

Metabolic Acidosis

PubMed

Ionized alkaline water: new strategy for management of metabolic acidosis in experimental animals.

2009

Hangovers

PubMed

Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats.

2017

ERW Superior to other H2Water

PubMed

Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water.