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Hydrogen Antioxidants (Molecular Hydrogen) Explained

Hydrogen Antioxidants (Molecular Hydrogen) Explained

Posted by Alkaline Water Plus on 13th Aug 2016

The main antioxidant in ionized water is basically free-hydrogen. Hydrogen (also called diatomic hydrogen, molecular hydrogen or free-hydrogen) is the single most effective and powerful antioxidant on the planet. When hydrogen is bonded to itself (H2) the bond is light. The extra electron (made by this bond) is free to bond with any free-radical and neutralize it easily and with no adverse effects.  

Hydrogen is only free in the state where it's bonded to itself. What it means to be "free" is that it can readily bond to free-radicals. By doing this, free-hydrogen neutralizes free-radicals more efficiently and powerfully than anything else. When hydrogen is bonded to itself, it's considered an antioxidant, but unlike any other antioxidant. Other antioxidants will lose their free electron and then could then potentially become harmful to the body if not eliminated quickly. Hydrogen is so small and light that it simply evaporates once the electron has been donated. In this way hydrogen has been found to be like a miracle molecule. It fights diseases like crazy, but causes zero bad side-effects.

Molecular hydrogen has been studied in both animal and human studies for many years. Research in just in the past decade indicates that about every single organ in the body and nearly every major disease has been found to benefit from it. 

Molecular Hydrogen Explained

To explain further, Dr. Ohta from Nippon Medical School (the grandfather of molecular hydrogen studies, himself) tells us in plain, laymen’s terms how important his findings are to all of medicine. Molecular hydrogen benefits are medically sound and proven at this point. Dr. Ohta authored a groundbreaking study, published in 2007, showing that molecular hydrogen neutralizes even the most deadly free radicals and causes no harm to the body. This amazed the world of medical researchers and spurred on a deluge of other medical research on the subject of molecular hydrogen, all of which have validated Dr. Ohta's original research.

What is molecular hydrogen? When you have two hydrogen joined together, under the right conditions, they bond and form a molecule (molecular hydrogen…a super tiny, yet powerful, molecule). Each molecular hydrogen molecule has extra electrons that can be safely donated to fight free radicals in the body.

The video is in Japanese, but is captioned. It is well worth taking the few minutes of your time, and a little patience, to watch. 

Here are excerpts from the video:

  • Hydrogen is very powerful. In the world, many people are studying this.
  • Our first publish was in 2007. Actually our hydrogen study started in 2005. It took 7 years to gain public recognition gradually.
  • Hydrogen can neutralize the oxygen radicals.
  • Remember the periodic table of elements? Hydrogen is the first, smallest element. When you put 2 hydrogen together, it becomes H2. This is hydrogen molecule. 
  • Actually hydrogen is soluble to both water and oil. The outside of the human cell is oil whereas the inside is water. Because it is soluble to both oil and water and it’s very small, it goes into human body easily. So, hydrogen can actually go into impaired cells and it can neutralize the strongest oxygen radical to inactivate oxygen radicals. 
  • Although invisible, H2 is measurable. Hydrogen has two functions. 1) To combine with oxygen radicals and neutralize them. When hydrogen combines with oxygen it becomes water. 2) It increases the enzymes that diminish oxygen radicals.
  • Some oxygen radicals are necessary to our body. Therefore we divide oxygen radicals up into good oxygen radicals and bad ones. My research was about how to remove the bad oxygen radicals without removing good ones. Hydrogen has the characteristic of removing the bad ones and keeping the good ones.
  • Hydrogen doesn’t just scavenge radicals. It also distinguishes them and only removes bad ones.
  • The disadvantage of oxygen radicals is it’s the root cause of various diseases. Cancer has its causes, stroke has different ones, but the root cause of both are oxygen radicals. That is why hydrogen inhibits cancer and it also inhibits or even cures strokes. 
  • Actually there’s a clinical study on human strokes. Hydrogen had been used on human patients. The study of hydrogen therapy on human stroke had already been published. Hydrogen therapy has already come to this stage.
  • Re: Longevity… I don’t think drinking hydrogen water will help people live up to 150 or 200, but it might be able to help most of us live healthily to 100. 

More about Molecular Hydrogen and Why It’s so Special

There are plenty of antioxidants available in food, so why would one more antioxidant be so special? The first reason is size. Because of its extremely tiny size, molecular hydrogen can get into the cells to repair them, whereas other antioxidants are too large to do this.

The second reason is solubility. Molecular hydrogen is unique in that it is soluble in both water and oil. This makes it uniquely able to penetrate cell membranes to get in, fight free radicals and even repair cells after they have been damaged.

Third, it is completely safe. Some antioxidants become free radicals themselves, at least temporarily, after they donate their electron. However with molecular hydrogen, even after donating its extra electron to the most dangerous radical of all, the oxygen radical, it joins with oxygen (H2+ O) to become harmless, neutral, water to be safely eliminated from the body.

Fourth, the fact that it only removes the bad free radicals, and leaves the useful ones alone, is significant in helping the body maintain homeostasis.

Finally, the fact that molecular hydrogen signals the production of enzymes in the body which reduce the bad free radicals is icing on the cake! 

Let's put it all of the above together with an example. Say you were inventing a device that would automatically clean up trash in the neighborhood. You would probably want it to be 1) small, 2) versatile (able to maneuver in and out of all kinds of places), 3) safe, 4) able to distinguish the actual trash (and not remove the good stuff), and finally you'd really know you had a winner if you even found a way to reduce the amount of trash produced in the first place.

How do You Get Molecular Hydrogen?

Molecular hydrogen can be administered in a hospital as a gas or and injection, but the safest and most user-friendly way to dispense molecular hydrogen is to dissolved it in water. Here are several cost-effective devices listed in order of effectiveness. 

  1. ** Water ionizers can deliver from .05 to 1.5 ppm of molecular hydrogen on a continuous-flow basis. They usually hook to your sink and can provide the whole family with fresh, molecular-hydrogen-rich water on demand and as much as you want. Because of such a wide diversity, look for machines that are specially configured to deliver high amounts of molecular hydrogen, such as the Smart 7P - Now With Molecular Hydrogen. Cost Analysis: 20 cents per liter (quart).
  2. **H2-tablets (which are dissolved in water) are capable of about .5 to 1.0 ppm of molecular hydrogen. Cost Analysis: 80 cents per liter (quart).
  3. ** Filtering devices, such as the Alkaline Ionizer Purifier Energizer are capable of delivering up to about .3 ppm of molecular hydrogen, depending on how much you filter at any one time.  

* Medical grade is considered to be from .5 to 1.5 ppm of molecular hydrogen in 2 liters of molecular-hydrogen-rich water per day. Medical grade is the amount used in Dr. Ohta's research and other, subsequent research.

**Though a few of the devices are capable of producing medical grade levels of molecular hydrogen, not all brands and models of water ionizers and ionizing/filtering devices can do this. 

Note: It probably isn’t necessary to get the full medical grade dose of molecular hydrogen to experience benefits. Many people have been experiencing benefits using water ionizers that have high ORP, but less than .4 ppm of molecular hydrogen (which is under the “medical dose” of the Hmolecule). There is definitely a lot more research that needs to be done, including doing a better job of standardizing the measurement techniques used.

Research on Molecular Hydrogen 

Professor Ohta’s ground-breaking research in molecular hydrogen in 2007, Hydrogen acts as therapeutic antioxidant…, was published in the Nature Medicine journal. Because this is such a famous medical journal, read by thousands of doctors and researchers every month, hundreds of medical research scientists who read his work were so inspired that they did their own molecular hydrogen research to study the subject further. (Note: All studies show promise for molecular hydrogen as an effective treatment…no matter what the body part or what the disease. No adverse effects were reported.)

Professor Ohta obviously inspired researcher, Tyler LeBaron, whose expertise is as a biochemist. Mr LeBaron was so impressed with Dr. Ohta's work that he spent a year in Japan (reviewing and observing the front-line medical research being done there. In this video he shares his enthusiasm for molecular hydrogen and his understanding of the research being done around the world, along with its importance. He points out that molecular hydrogen is not only the most powerful antioxidant, itself, but it also has the power to recharge other antioxidants and trigger many healthy processes in the body. It is an anti-inflammatory, anti-allergen, and anti-obesity agent as well.

The list, below, are not citations for this article, but meant to be a partial list to demonstrate much of the follow-up research that Professor Ohta's research inspired. Simply copy/paste the date and title of any research article into your browser to see the full data about each.

General Molecular Hydrogen Research (All organs/All diseases)

(2016) The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives. 

(2016) Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model 

(2015) Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications . (2014) Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. 

(2013) The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance . 

(2012) Electrolyzed-reduced water confers increased resistance to environmental stresses. Molecular & Cellular Toxicology

(2012) Hydrogen holds promise as a safe and effective antioxidant for alcohol . 

(2010) Extension of the Lifespan of Caenorhabditis elegans by the Use of Electrolyzed Reduced Water. Bioscience Biotechnology and Biochemistry 

(2007) (published in Nature Medicine Magazine) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals . Dr. Ohta’s groundbreaking research.

(2005) Protective effect of electrolyzed reduced water on the paraquat-induced oxidative damage of human lymphocyte DNA. Journal of the Korean Society for Applied Biological Chemistry

Molecular Hydrogen Research Related to Bones

(2013) Hydrogen water consumption prevents osteopenia in ovariectomized rats.

(2013) Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast.

Molecular Hydrogen Research Related to Brain

(2011) Hydrogen is neuroprotective against surgically induced brain injury.  

(2011) The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles. 

(2010) Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress.  

(2010) Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress.  

(2010) Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice.  

(2009) Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice.  

Molecular Hydrogen Research Related to Cancer

(2012) Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells. 

(2011) Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging.

(2011) Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.

(2009) Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol.

(2008) Neutral pH Hydrogen-Enriched Electrolyzed Water Achieves Tumor-Preferential Clonal Growth Inhibition Over Normal Cells and Tumor Invasion Inhibition Concurrently With Intracellular Oxidant Repression. Oncology Research

(2008) Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biological & Pharmaceutical Bulletin

(2007) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. (2004). Suppression of invasion of cancer cells and angiogenesis by electrolyzed reduced water. In Vitro Cellular & Developmental Biology-Animal 

Molecular Hydrogen Research Related to Exercise

(2015) Molecular hydrogen in sports medicine: new therapeutic perspectives. 

(2012)Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.

(2008) Effect of hydrogen saturated alkaline electrolyzed water on urinary oxidative stress markers after an acute exercise: A randomized controlled trial.

Molecular Hydrogen Research Related to Eyes & Ears

(2016) The potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases.

(2009). Hydrogen protects auditory hair cells from free radicals.

2010). Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia–reperfusion injury. 

Molecular Hydrogen Research Related to Heart

2012) H 2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model.

(2012) Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. 

(2011) Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice.

(2010) The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice.

Molecular Hydrogen Research Related to the Liver

(2015) Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity

(2014) Effects of oral intake of hydrogen water on liver fibrogenesis in mice.

(2013). Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells.

(2013). Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning.

(2012) Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine.

(2011) The protective role of hydrogen-rich saline in experimental liver injury in mice.

(2010) Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice.

(2009). Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice.

(2009) Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation

Molecular Hydrogen Research Related to Metabolic Syndrome

(2010) Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level, in Animal Cell Technology: Basic & Applied Aspects. 

(2010) Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.

(2009) Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells.

(2009) Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis.

(2009) Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats.

Molecular Hydrogen Research Related to the Mouth

(2015) Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model. 

Molecular Hydrogen Research Related to Parkinson's Disease

(2016) A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. 

Molecular Hydrogen Research Related to the Pancreas

(2016) Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis.

(2012) Experimental studies of effects of hydrogen-rich saline in rats with severe acute pancreatitis

(2012) Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats.

(2010) Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. 

Molecular Hydrogen Research Related to the Muscles

(2013). Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats.

Safety of Molecular Hydrogen Research

2011 Evaluate of Electrochemical Characteristics in Electrolyzed Reduced Water.

Molecular Hydrogen Research Related to the Kidneys

(2012) Hydrogen-rich water inhibits glucose and alpha,beta -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney.

(2012) Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity.

(2011) Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging.

(2010) Oral hydrogen water prevents chronic allograft nephropathy in rats.

(2010) Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT.

(2008) Electrolyzed water reduces urinary protein excretion in the streptozotocin induced diabetic Dahl salt sensitive rats.

(2007) Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed

Molecular Hydrogen Research Related to the Lungs and Other Organs

(2013) Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.

(2013) Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury.

(2013) Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma.

(2012) [Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury].

(2012) Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats.

(2012) Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis.

(2011) Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model.

(2011) Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation.

(2011) Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats.

(2011) Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice.

(2011) Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury.

(2011) Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress.

(2010) Hydrogen inhalation ameliorates ventilator-induced lung injury.

(2010) [Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation].

(2010) Saturated hydrogen saline protects the lung against oxygen toxicity.

Molecular Hydrogen Research Related to the Skin

(2013) Protection by hydrogen against gamma ray-induced testicular damage in rats.

(2013) The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice.

(2012) Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.

(2012) Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig.

(2012) Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.

(2011) Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice.

(2011) Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice.

(2010) Radioprotective effect of hydrogen in cultured cells and mice.

(2010) Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage.

Molecular Hydrogen Research Related to the Spine

(2010) Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats.

Cathleen Lograsso

Cathleen LoGrasso

My background is in physiology, teaching, nutrition and weight loss. I have raised 5 children who are all grown now. I have a masters degree in education and was a teacher/principal for 24 years. I created Alkaline Water Plus in 2009 to educate people about the benefits of ionized water.

The very best thing I have ever purchased is a WATER IONIZER, and I've been in perfect health ever since I started drinking ionized water 25 years ago!

Cathie LoGrasso Owner, Alkaline Water Plus

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